• A profound well characterized and frequently cited hallmark

  2019-07-06

  

  A profound, well-characterized, and frequently-cited hallmark of cardiac aging is impaired diastolic function. In addition to decreased LV end diastolic volumes in humans and reduced cardiac tube diastolic diameters in flies, several indices of age-related diastolic dysfunction are shared among the

• In the vasculature the interaction

  2019-07-05

  

  In the vasculature, the interaction of VE-cadherin and β‑catenin at endothelial cell-cell junctions controls vascular integrity [33]. However, OxLDL induces the activation of β‑catenin in human aortic smooth muscle cells, and the active β‑catenin associates with TCF4 and translocates into the nucleu

• Histone PTMs play a significant role throughout brain develo

  2019-07-05

  

  Histone PTMs play a significant role throughout CCK-8 price development, maturation, and aging and dysregulation of histone PTMs and genes/enzymes regulating these marks have been associated with alterations in the normal course of neurodevelopment and with a plethora of neurological and psychiatri

• br Introduction Japanese encephalitis JE is an acute infecti

  2019-06-24

  

  Introduction Japanese encephalitis (JE) is an acute infectious disease of the nervous system caused by Japanese encephalitis virus (JEV), which is primarily transmitted through mosquitoes. There are around 68,000 cases of JE annually worldwide, resulting in a mortality rate of approximately 10–30%. Among survivors, around 30–50% exhibit severe neurological sequelae [1].

• Historically the introduction of caesarean section surgery w

  2019-06-24

  

  Historically, the introduction of caesarean section surgery was associated with an improvement in maternal and perinatal health outcomes. WHO has stated that no empirical evidence exists for an ideal caesarean rate, but “what matters most is that all women who need caesarean sections actually recei

• br Raising taxes on tobacco is the measure with the

  2019-06-24

  

  Raising taxes on tobacco is the measure with the “least compliance” worldwide among the set of measures introduced by the WHO to facilitate implementation of its Framework Convention on Tobacco Control programme. In an extended cost-effectiveness analysis, Stéphane Verguet and colleagues (April, 2

• 3X FLAG Peptide Exposure levels are often high in preclinica

  2019-06-20

  

  Exposure levels are often high in preclinical safety studies, but if exposure is low or absent, a positive signal will potentially be lost in the CIC assay. The intended use of the CIC assays established by Stubenrauch et al. and Carrasco-Triguero et al. [8,12,19] were measurement of total ADAs, thu

• The current study showed that self ratings

  2018-12-12

  

  The current study showed that self-ratings with the SFS could predict total working hours in recent months. Self-reports have sometimes been considered to be less reliable compared to performance-based assessment or informants’ observations, partly due to poor insights of patients (for a review, Bellack et al., 2007; Durand et al., in press).

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